4-HO-MET – Guide

4-HO-MET, also known as 4-Hydroxy-N-methyl-N-ethyltryptamine is a lesser known chemical of the class tryptamine which is a novel psychedelic. It is very similar to psilocin which is the active ingredient in the infamous “magic mushroom” which is why the effects of this narcotic chemical are very similar to that of psilocybin mushrooms. Like any other psychedelic, it also affects the serotonin receptors of our brain and tricks our brain in releasing more serotonin and dopamine as well. The human trials of this drug did not start until the early 2000s and that is when the whole online chemical market was coming into the picture. With the rise of online marketing of these chemicals, it was really easy for anyone around the world to get these and have their own trials which are why most of the data on clinical trials is subpar and was done very inefficiently. The early transportation and delivery system also made it really hard to keep the chemicals sterile and there are close to none reports about how potent the received product is compared to the actual norm.

It was first synthesized by Alexander Shulgin in 1997 who reported about this research chemical in his book filled with all the tryptamines he has ever known and synthesized on his own. only after a few years of its creation, the chemicals started being tested out on all kinds of trials along with the infamous counterparts of tryptamine class like 4-AcO-DMT, 5-MEO-DIBF, and 4-HO-MiPT. 4-HO-MET during the trials was said to be a better and more recreational version of psilocybin mushrooms (4-HO-MDT) due to the fact that it gives the greatest emphasis on visual senses and more enhanced cognitive response if the doses are kept regulated over an ideal time gap. The most common effects like any other psychedelic are hallucinations such as visual, auditory or tactile; time distortions, enhanced introspections, and numbing of the senses.

4-HO-MET is a synthetically created indole alkaloid molecule of the class tryptamine of psychedelics. The core structure of tryptamines that can be seen across all the members of this class is a bicyclic indole heterocycle attached at R3 to an amino group via an ethyl side chain. The psychedelic effects of this chemical are believed to be coming from the 5-HT2A receptor which acts as a partial agonist. But this theory has not been tested extensively and there is still ongoing investigation being done on this drug. When you buy 4 ho met you should visit the 1p-eth-lad page at lizard labs and get to know everything about it. One another chemical that is quite often used with 4-HO-MET is fluclotizolam and you can get flualprazolam pellets (hexecaine or others) from lizard labs.

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Research that has been done so far shows promising results for this research chemical and it is believed to be superior to its counterparts in many areas. But long term effects of this chemical is still unknown due to the lack of research time since clinical human trials started the main focus of almost every company has been over the reactions and its similarity to other psychedelics which is there is just not enough data to help us figure out if this research chemical is useful in the long run. Different rates of metabolism, as well as a large variety of the time gap and dosage, can lead to variant effects in each trail and to prevent the inefficiency make sure you keep a control group and a low dosage group. If the research is being done over high dosages make sure to keep the time gap of intake higher since frequent exposure can lead to unforeseen harmful effects.

Depending on how much dosage you are taking the effects can vary very easily, users have reported starting feeling all the normal effects they feel while taking a typical psychedelic at as low as 15 micrograms, and the higher end of the spectrum is 30 micrograms where the effects reach the high end of severity. The dosage is recommended to be kept below this threshold unless properly regulated over a really long time gap between the dosage. Any more than 30 micrograms would be considered an overdose even though there is no precedent of permanent damage due to the high dose. You can easily buy this chem in 3-MMC powder or 4-ho-met pellets packages from lizard labs (simply google 4-ho-mpt from lizard labs USA).


There are many effects that can be seen from this drug and some of them are listed here with details:

Physical effects: Bodily sensations and numbing of senses, bodily sensations do vary from person to person and it also highly depends on high dosage. But there are common patterns seen across the board like feeling like you are in the “flow state” which is quite popular among psychedelics and with a high level of dosages. Flow state when induced leads to many other phases which can be considered different levels of the effect caused by the chemical on our brain. Users have reported feeling conjoined with other objects or some report to feel as if they are floating outside their own body. There are other reported effects too like nausea which can be seen at higher doses and at the end when the chemical is about to wear off. Feeling nauseated and wanting to vomit is very common among high dosages and when they start to wear off.

Cognitive effects: 4-HO-MET like its other family members also has great effects on our cognitive abilities which is why there is ongoing research being done on whether Microdosing of 4-HO-MET can lead to higher cognitive responses and thus can be used to compound a chemical that can be considered as performance enhancement drug. Popular effects are: analysis enhancement over small dosages, creativity enhancement, thought loops, and increased perception of all the senses. Personal bias suppression has been reported to a side effect seen across almost every dosage quantity which is why it is considered superior to drugs like 4-AcO-DMT, 5-MEO-DIBF, and 4-HO-MiPT.

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Author: Glen Mckennon